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In this study, we observed a distinct pattern of CBF alterations in the prefrontal and limbic regions, suggesting a region-specific mechanism of dysfunction

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Furthermore, even the 75 mg/kg dose of metformin, which did not affect pyruvate tolerance, continued to lower blood glucose in the presence of exendin(9-39) (ESM Fig

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Its claim is that GLP-1 agonists show differential efficacy depending on baseline metabolic phenotype, so these values inform prescribing intensity and choice of agent rather than a simple yes-or-no decision