doi: 10.1016/j.cmet.2022.06.002
Lactic acidosis reports were markedly lower with combination therapy (567 vs 15,789), as were acute kidney injury (675 vs 7,694), diarrhoea (3,890 vs 6,922), and metabolic acidosis (203 vs 4,713), suggesting that the addition of GLP-1 RAs to metformin may mitigate serious adverse effects associated with metformin alone (Table 2)
Mol Cells (2018) 41(3):23443
For example, a plan may cover Ozempic for someone with type 2 diabetes but deny it if it's being prescribed solely for weight loss
These may play a key role in the high increased half life of the Semaglutide-GLP-1R complex (165+ hours, compared to the ~13 hours in the case of Liraglutide)
Alternative and New Treatments Goldberg discusses exciting immune therapies, including dendritic cell therapy, which shows promise in cancer treatment