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A trial of chelation therapy to treat autism registered on the US National Institutes of Health (NIH) website is indicated as completed, with the last update October 13, 2009 [91]

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The disease is a macrocytic anaemia caused by a vitamin B12 deficiency, which, in turn, is the result of intrinsic factor deficiency, a protein that binds avidly to dietary vitamin B12 and promotes its transport to the terminal ileum for absorption