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2) The study conducted by the research team of Li et al meticulously delineated the role of FOXO4 in Leydig cell senescence and its impact on male fertility, while also demonstrating the therapeutic efficacy of FOXO4-DRI in alleviating age-related testosterone and spermatogenesis insufficiencies

In vitro investigations have revealed that the ovarian steroidogenic enzymes responsible for androgen production are stimulated by oxidative stress and inhibited by antioxidants such as statins (91, 92)

However, clinical trials are still lacking to confirm these findings in humans ( Table 1 )

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1-2 capsules of 500 mg each, twice daily

The advantages observed from this proof-of-concept trial continued 12 months after exenatide cessation [17, 86]