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Furthermore, meta-analysis including 165 clinical trials reaffirmed these findings showing no evidence of elevated risk of pancreatitis or pancreatic cancer [69], assuring the safety of alogliptin

Both preclinical and clinical studies were included if they evaluated the effects of GLP-1 RAs on the major biological processes encompassed by the 12 hallmarks of aging, such as mitochondrial dysfunction, insulin resistance, dysbiosis, inflammaging, autophagy, proteostasis, and genomic stability

Reduced CCK signaling in obese-prone rats fed a high fat diet

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DPP-4 inhibitor enhanced insulin secretion and induction of autophagy signals in the islets of high-fat-fed mice