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GLP-1 usage has surged, but many stop treatment prematurely While high costs may play a role in discontinuation, cases where side effects prompt patients to stop treatment should raise concerns for plan sponsors about the significant upfront investment required to initiate these therapies

ATP-binding cassette subfamily C member 2 (ABCC2) can be induced by oxidative stress in various cancer cells, enhancing its capacity for GSH efflux, thereby promoting lipid ROS accumulation and increasing cellular sensitivity to oxidative stress and ferroptosis (95)

However, the poor bioavailability of pirfenidone and the lack of tumor specificity have limited its efficacy

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Manage stress levels Chronic stress may deplete glutathione over time

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