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The abnormality occurs when senescent cells are not discarded by the immune system, have been persistently generated by nearby cells via expression of SASP, or are subjected to chronic injury

To confirm this, we treated HUVECs with the proteasome inhibitor MG132 and the protein synthesis inhibitor cycloheximide (CHX, 10 g/mL)

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74 Recently, a prime/boost immunization strategy was shown to facilitate Fc-mediated phagocytosis