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Fatigue is uncommon in clinical trials (under 1%) but may be more frequently reported in real-world use, especially during the early weeks of treatment

Mounjaro contains tirzepatide, which triggers GLP-1 but also adds a second hormone called GIP

The South African product information lists a step-up dosing schedule, with strengths from 0.25 mg to 2.4 mg, reflecting its design as an obesity-treatment medicine

Rybelsus (oral tablet) Used to treat type 2 diabetes in adults

Clinical trials have shown this dose produces significant weight loss over 56 weeks, with many participants achieving 510 % of baseline body weight reduction