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Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease

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Cyanocobalamin is the most commonly used form of vitamin B12 in supplements and injections, while methylcobalamin is a more natural form of vitamin B12 that is found in some foods

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These include: Commercial weight management programmes (such as Weight Watchers/WW, Slimming World) that provide group support, structured meal plans, and accountability NHS-funded programmes including the NHS Digital Weight Management Programme, which offers evidence-based support for eligible patients Cognitive behavioural therapy (CBT) approaches that address psychological factors contributing to overeating and weight gain Dietary approaches with good evidence include: Mediterranean-style diets emphasising whole grains, fruits, vegetables, legumes, nuts, olive oil, and moderate fish consumption Low-calorie diets (1,200-1,500 kcal/day for women, 1,500-1,800 kcal/day for men) with balanced macronutrient distribution Very low-calorie diets (800 kcal/day) for short periods under medical supervision, particularly for patients with type 2 diabetes Bariatric surgery represents the most effective intervention for severe obesity (BMI 40 kg/m, or 35 kg/m with comorbidities)