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Expression of cytokines and growth factors Wound skin tissue samples were collected from sacrificed mice on the 3rd day and immersed in normal saline, mechanically broken into tissue homogenate, and the supernatants were collected

[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Bi L., Liu Y., Yang Q., Zhou X., Li H., Liu Y., Li J., Lu Y., Tang H

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found that the activation of mitophagy through the modulation of the Nrf2/ARE signaling pathway exerted beneficial effects against DN and that the ROS-targeting antioxidant, mitoTEMPO, not only restored mitochondrial mitophagy, but also improved renal function in db/db mice co-treated with ML385 (Nrf2 inhibitor) and coenzyme Q10 [100]

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Science has known this to be true for the older niacins (NA and NAM) for many decades, with, as an example, NA lowering cholesterol while NAM does not