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Continuous ROS production results in oncogene and tumor suppressor gene changes, as well as chromosomal abnormalities by oxidative genome damage, which includes the oxidation of guanine to form 8-OhdG and 8-oxo,7,8-dihydroguanosine (8-OHG) in RNA and DNA (100)

Peptides with cationic motifs utilize electrostatic interactions to target and bind negatively charged phospholipids in cell membranes, thereby facilitating their entry into cells 55

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Reduced glutathione (in 100 mM K 2 HPO 4 /KH 2 PO 4 buffer, pH 7.0) was automatically injected to the indicated final concentration using the built-in injectors

The strongest case is for patients who have failed standard titration at multiple dose levels