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doi: 10.1016/j.cell.2012.06.035 118 KimbungSJohanssonIDanielssonAVeerlaSEgyhazi BrageSFrostvik StoltMet al

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Of 6263 patients, 3131 were randomized to FARXIGA 10 mg and 3132 to placebo and were followed for a median of 28 months

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Neural-Circuit Connectivity While hypothalamic MC4 signaling is well established in appetite-control pathways, downstream projections involving mesolimbic reward regions and autonomic brainstem centers remain incompletely characterized experimentally