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This aggregation is often irreversible

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The difference between a 98% pure peptide and an 85% pure one might seem minor, but that 13% impurity can include problematic compounds

It's important to note that long-term use of certain diabetes medications, including GLP-1 receptor agonists like semaglutide, may be associated with an increased risk of vitamin B12 deficiency [1]

The enthalpy of binding increased steadily with the number of histidine residues from ~10 to ~60 kJ/mol

Chemosphere 297 , 134132 (2022)