guaifenesin and semaglutide Navigating Cold & Flu Season on GLP-1 The extended Wegovy drug interactions: 12 medications

Balkan Med J (2017) 34(3):21925

It is an FDA-approved treatment for obesity and is also being studied as a potential treatment for type 2 diabetes

Inzucchi SE, Docherty KF, Kober L, et al

However, in the treated group, the reduction in tinnitus incidence at 16 kHz and 20 kHz was substantially greater than the slight increase observed at 9.3 kHz and 24 kHz following NHPN-1010 treatment

What they found: 4,192 human genes change expression by 2 in response to GHK-Cu (31.2 % of the human genome) Of these 2,296 genes up-regulated , 1,896 down-regulated Pattern of changes: a rejuvenating signature, genes typically associated with ageing are down-regulated, regenerative genes up-regulated DNA repair , strong up-regulation of genes in BER, HR, NER pathways Mitochondrial biogenesis , increase in the number of mitochondria in cells Anti-apoptotic signal , protection against cell death Down-regulation of cancer signals , some oncogenes decreased Why it matters: This is the strongest evidence for the pleiotropic nature of GHK-Cu

Other GLP-1 receptor agonist trials have yielded mixed results regarding retinopathy risk