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Novo Nordisk files for FDA approval for CagriSema, the first once-weekly combination of GLP1 and amylin analogues owenhaskins Dec 19, 2025 2 min read Novo Nordisk has submitted a New Drug Application (NDA) to the FDA for once-weekly CagriSema (cagrilintide 2.4 mg and semaglutide 2.4 mg) injection, to be used with a reduced-calorie diet and increased physical activity, to reduce excess body weight and maintain weight reduction long term in adults with obesity or overweight in the presence of at least one weight-related comorbid condition

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Pharmacological studies For assessment of drug effects under room temperature (22 2 C), male age-matched mice were double housed and fed with a 58% HFD (D12331, Research Diets) for approximately 20 weeks, followed by random assignment into groups of matched genotype, body weight and body composition

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Scientific Overview A synthetic 13-amino acid linear melanocortin analog studied for receptor binding affinity, melanin production pathways, and signaling activity in research models