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The cacao fruits and especially the seeds in it need no introduction as everyone knows them as the magical raw material of the magical sweet treat, chocolate (the flavour is composed of more than 1200(!) substances, and the exact chemical nature of it is not really understood, so it's indeed magic

But the largest study to date, an NIH-funded collaboration between U.S

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TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: compounds pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development