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However, if you have lost significant weight while on tirzepatide, your body composition has changed permanently, at least until weight regain occurs, and your levothyroxine dose should reflect your current weight rather than your pre-treatment weight

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[PMC free article] [PubMed] [Google Scholar] Hamby ME, Coppola G, Ao Y, Geschwind DH, Khakh BS, Sofroniew MV (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors

iv) blinding of outcome assessment