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The degree of melanin pigmentation is determined by the number and distribution of melanocytes in the basal cell layer of the oral epithelium of each anatomical region, by their melanogenic activity, by the degree of arborisation of the dendritic processes of the melanocytes, and by the number, size, and distribution of melanosomes in the melanocyte-keratinocyte unit [46]

There are 7 key areas that need to be considered for autoimmune progesterone dermatitis treatment: Stopping or changing progesterone exposure Antihistamines Dietary strategies Steroids (short-term) Hormone suppressants Desensitization protocols Supportive supplements Stopping or Changing Progesterone Medications Synthetic progestogens, often found in contraceptives 5 or fertility treatments, can trigger APD symptoms

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