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The enzyme glutamine synthetase binds ammonia to glutamate to form L-Glutamine, effectively trapping the toxic nitrogen

Since liver is a major player in metabolism, this approach also provides mechanistic quantitative information on the molecular pathways that are affected by drug toxicity 34

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The global type 1 diabetes market size is calculated at $37.60 billion in 2025 and is predicted to increase from $40.54Bin 2026 to approximately $79.14B by 2035, expanding at a CAGR of 7.73% between 2026 and 2035

The primary phospholipid in VLDL particles that transport triglycerides out of the liver into circulation where peripheral tissues can oxidise them for energy