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If evoke/evoke+ were to confirm such an effect size, it would position semaglutide as a novel modality offering several potential advantages over anti-amyloid therapies such as Lillys donanemab, e.g., oral formulation, simpler diagnostics, likely no need for PET scan monitoring

Mitochondrial and peroxisomal -oxidation can elevate reactive oxygen species, and myelin breakdown may generate bioactive lipid intermediates that can amplify neuroinflammation (Tiwari & Simons, 2025)

Dulaglutide (Trulicity), another once-weekly GLP-1 agonist, reports injection site reaction rates of approximately 0.7% in its FDA label

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24 , 497w504 (2018)