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Aromatic-turmerones anti-inflammatory effects in microglial cells are mediated by protein kinase a and heme oxygenase-1 signaling

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In the acute phase of SARS-CoV infection, there is erosion of the epithelial cells that line the airways and accumulation of debris and particles that obstruct the regular breathing pattern [28,29] There is also a risk of progression to more severe complications such as acute lung injury (ALI) and the subsequent Acute Respiratory Distress Syndrome (ARDS), which cover alveolar damage [27]

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This metabolic adaptation utilizes the spare capacity of mitochondria to fulfill increasing energy demands

[13] Thirdly, tyrosinase inhibition is effected indirectly via its antioxidant effect