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That sounds technical, but heres the simple version: these drugs act as a natural hormone in the body called GLP-1, which helps regulate blood sugar, slows digestion, and signals feelings of fullness

In contrast, human and pig islets express DPP4 almost exclusively in cells (130, 131)

A dedicated head-to-head diabetes trial (SURPASS-2) did show tirzepatide lowering HbA1c and body weight more than semaglutide 1 mg, though that used a lower semaglutide dose than the weight-management products

doi:10.1016/s2213-8587(18)30104-9

Int J Sport Nutr Exerc Metab, 10(22), 199-207

If nausea persists beyond seven days or causes inability to keep fluids down, contact your provider about dose reduction or anti-nausea medication like ondansetron