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Research suggests BPC-157 may downregulate VEGF expression in tumor contexts while upregulating it during normal healing

In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)

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& McIntosh, C

Small intravenous human studies reported changes in sleep onset, sleep efficiency, total sleep time or daytime functioning in some settings

Some people find that depression can make it hard to address underlying issues