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This gender gap appears in non-clinical populations as well, suggesting a broader pattern

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Peripheral but not central administration of GLP-1 fails to inhibit angiotensin (ANG) II-induced drinking in rats that have been treated with monosodium glutamate (MSG) to induce damage of the ARC and the sensory circumventricular organs, suggesting that peripherally administered GLP-1 effects drinking behavior via CNS-dependent mechanisms [760]

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It can also undo the benefits of losing weight, which makes heavy alcohol use dangerous during treatment

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