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In our hands, S458D did not disrupt DDD-COP1 assembly or architecture by negative-stain EM, although we cannot exclude functional effects in cells or more subtle conformational changes

Blumenkrantz MJ, Kopple JD, Gutman RA, Chan YK, Barbour GL, Roberts C y cols

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J Food Process Preserv 43:e14105

Glucagon-like Peptide-1 Receptor Agonists Associated Gastrointestinal Adverse Events: a Cross-Sectional Analysis of the National Institutes of Health All of Us Cohort