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Glucose deprivation reduces the PPP-mediated NADPH generation, making it impossible to reduce insoluble cystine imported via xCT to a more soluble cysteine, thereby inducing disulfide stress (i.e., cystine-dependent toxicity) and leading to rapid cell death [48] [Figure 3B]

Baral, P.S

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Hair Cortisol and Adiposity in a Population-Based Sample of 2,527 Men and Women Aged 54 to 87 Years