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The axons of RGCs form long-extending nerve fiber bundles, the structural and functional maintenance of which necessitates the generation of considerable amounts of ROS by mitochondria (94)

doi: 10.1038/nature12726 234 VaccaMCelanoGCalabreseFMPortincasaPGobbettiMDe AngelisM

The study provided indirect evidence that inducing ferroptosis may be a potential therapeutic option for rescuing selenium-induced defects in embryonic eye development (136)

Ferroptosis is implicated in IBD, particularly in the death of intestinal epithelial cells (81)

Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition

This rationale was suggested in the studies that found that redoxins are induced in stressed cells ( In vitro studies have confirmed that molecular oxygen, superoxide, and H 2 O 2 all have the capacity to oxidize thiols, and among these H 2 O 2 stands out ( E