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Crucial cytokines including IL-1, IL-6 and TNF- are essential for sustaining the chronic inflammatory state associated with RA [232, 233]

These may include flushing, itching, hives, digestive upset, headaches, nasal symptoms, food reactions, heart racing, or sensitivity to heat, stress, alcohol, fermented foods, or medications

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Knockout of mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 (mtGPAT1), a major hepatic glycerol-3-phosphate acyltransferase, decreased de novo DAG generation protecting mice from hepatic insulin resistance (195)