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Tirzepatide, marketed as Mounjaro for diabetes and Zepbound for weight management, works by activating GLP-1 and GIP receptors to regulate appetite and blood sugar

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Licensed injectable GLP-1 formulations in the UK include once-daily liraglutide and once-weekly semaglutide and dulaglutide

15 , A1034A1034 (2001)

Weight Regain After Discontinuation Clinical data consistently shows significant weight regain after stopping: STEP-1 Extension: Participants stopping semaglutide regained approximately two-thirds of lost weight within 12 months

Its role as an NNMT inhibitor highlights effects on metabolic function, endurance, and healthy aging