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Whilst indistinguishable in many respects, these empty capsids are inherently less stable than an infectious virus and prone to switching conformation from the native D-antigenic state to the less immunogenic C-antigenic structure 12

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Conclusions This review of published studies indicates that evidence for the involvement of the -glutamyl cycle and trans-sulphuration pathway in autism spectrum disorders should be further explored with higher quality and lower risk bias studies to in order to ascertain the significance of these pathways with respect to clinical outcomes