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62 In nose-to-brain delivery systems, nanoemulsions can overcome the limitations of drugs, such as poor bioavailability and water insolubility

Some people have experienced gastrointestinal symptoms, such as nausea, diarrhea, appetite suppression, heartburn, and abdominal discomfort, especially with daily doses 200 mg (109)

doi:10.1080/13813450701661198 Deepmala, Slattery J, Kumar N, et al

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Of note, female participation in Phase 3 trials has been higher relative to all trials in all reporting periods except for 2016 (the highest difference in relative representation of females was observed in 2013, where Phase 3 trials reported 64.2 percent females, while all trials reported just 44.3 percent females)