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Results GSH synthesis is required for the survival of adult animals To better understand the importance of GSH in adult mammals, we developed an inducible, whole-body Gclc KO mouse by breeding the Gclc f/f mouse strain 30 with the Rosa26-CreERT2 mouse strain 31

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Gastrointestinal discomfort may occur in some individuals

glutathione reductase (GR) catalyzes NADPH to reduce GSSG to regenerate GSH, while NADPH oxidizes to produce NADP+

10.1016/j.bbagen.2012.11.019 Biochim

Histology of mucosal biopsies Microscopically only minor morphological changes were observed in duodenal biopsies of cirrhotic patients and controls and did not differ significantly between the groups, such as a (slightly) increased number of intra-epithelial lymphocytes (n = 2 vs