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Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response

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Most of the iron is in the form suitable for binding with ferritin in the cytoplasm, which can be degraded by autophagy-lysosome pathway, causing the release of active iron 113

Nitrated HGF ( bar 3 , peroxynitrite-treated at 1:2000) lost its activation activity as demonstrated by a drop in the activation index down to the baseline level observed in the negative-control culture ( bar 1 ) 32 and in GSSSG/LASSS-cultures ( bars 6 and 10 , missing HGF)

Cell Mater 24, 117

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