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Histopathological analysis of the hippocampus was performed to assess neurodegeneration

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Therefore, these findings further support the observation that low IGF-1 preferentially benefits females, and suggest that a potentially broad therapeutic window to target IGF-1R signaling may exist in females, with greater benefit possible by initiating at even younger ages than implemented in this study

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That means it is not a safety problem that emerged during the large clinical trials that were done to test for safety and effectiveness