In a human clinical trial, a marked increase in glutathione levels was shown regardless of its initial (basal) concentration
This promotes a potent pro-inflammatory gene expression profile, enhancing glycolysis and the production of IL-1, thereby exacerbating chronic inflammation (64)
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M1-like macrophages, characterized by elevated glycolysis, disrupted TCA cycle intermediates, enhanced ferritinophagy, and high ROS/NO production, naturally promote ferroptotic pressure
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Murlentamab, a low-fucosylated anti-Mllerian hormone type II receptor (AMHRII) antibody, exhibits potent anti-tumor activity in ovarian cancer by reprogramming TAMs and activating T cells