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This release of histamine and tryptase increases blood flow to the skeletal muscles during exercise.[ref] Hypoxia has also been shown to induce mast cell degranulation.[ref] This is a normal response for most people, and the body can handle a certain increase in histamine and tryptase

It has been extensively studied in research settings for its interactions with wound healing models, collagen synthesis pathways, antioxidant activity, and gene expression regulation

Livestock Research for Rural Development, 30(9)

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This allows your physician to adjust dosing and monitor for any contraindications