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This does not affect the efficacy of the ingredients and is not a sign that the product has gone bad.

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In the gastrointestinal tract, COX-1-derived prostaglandins function to increase production of the thick mucus/bicarbonate layer that coats gastric surfaces and buffers them against stomach acid (Vonkeman 2010)

The authors would like to acknowledge Myung-Jin Kang and Nicholas Bentley for their comments on the manuscript

Under this analogy, the heart is the central pump, which pumps out water (blood) around a network of water pipes (our blood vessels)