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doi: 10.1038/s41583-022-00564-x 276 TokudaE.FurukawaY

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Research Protocol Summary Study Protocol: 0.25 mg AOD-9604 administered intra-articularly via ultrasound guidance Frequency: Weekly injections Duration: 4-7 weeks in research studies Combination Therapy: 6 mg hyaluronic acid co-administered for enhanced effects Assessment Timeline: Significant improvements observed by 8-9 weeks Note: These protocols are from animal research and have not been validated for human use

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Best choice for most 5 mg protocols: 2 mL of bacteriostatic water is the sweet spot for researchers taking 200-500 mcg doses