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Skeletal muscle, ligament, and bone-defect models have produced comparable healing-rate findings, summarized in the 2021 wound-healing review (PMID 34267654) and the 2025 musculoskeletal narrative review (PMID 40789979)

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A double blind, placebo control study showed a 28% reduction in mortality when IV NAC was administered after an acetaminophen overdose

Together, these findings show that ESA induces ferroptosis as a single agent and distinguishes ESA from arachidonic and adrenic fatty acids, which sensitize cells to GPX4 inhibition but do not induce ferroptosis 13,17

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