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153155 We showed that knockout mice that had no Rlip gene had 80% loss of GS-E transport activity and markedly increased levels of LOOH and 4HNE in tissues

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Clinical Significance of PDHc Mutations There is no pathway in mammals for the conversion of acetyl-CoA to glucose and therefore, the activity of the PDHc is highly regulated by a variety of allosteric effectors and by covalent modification

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