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What is a suitable substitute for Synjardy XR 51000 (metformin extendedrelease 1000 mg plus empagliflozin 5 mg) in a type 2 diabetic patient with adequate renal function and no contraindications?

Quick Answer: GLP-1 affects multiple brain regions including the hypothalamus, brainstem, mesolimbic reward system, hippocampus, and cortical areas involved in appetite regulation, reward processing, and cognitive function

The MHRA has not granted marketing authorisation for CJC 1295 or ipamorelin for any clinical indication

Interestingly, no significant differences were observed in the qPCR results of Pdx-1 , Foxo1 , and NeuroD1 across all treatments (Figure 5B(a))

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