In fact, it is the number one reason people are so interested in this little amino acid these days
GHRH stimulates GH synthesis and release, while ghrelin mimetics amplify the release signal and inhibit somatostatin (the hormone that normally suppresses GH between pulses)
Another interesting facet of the maintained adaptive response is that the GSH level of roughly 250-300 M may not be arbitrary
Curr Biol 27:10051012 Hanzlikova H, Caldecott KW (2019) Perspectives on PARPs in S phase
As an added bonus, the new gepant class of medication does not appear to create any risk of medication adaptation headache
CJC-1295 DAC carries the most extensively published clinical research profile of any GHRH analogue currently available as a research compound, with two randomised controlled trials in healthy adults, pre-clinical knockout mouse data, and a serum proteomics study providing a well-rounded evidence base