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Sirt1 and the mitochondria

That is, dihydroorotate (DHO) is oxidized to orotate (OA), and at the same time electrons are transferred to ubiquinone in the inner membrane of mitochondria, which is reduced to dihydroubiquinone [51]

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Handa K, Inukai K, Onuma H, Kudo A, Nakagawa F, Tsugawa K,

The primary aim was to determine AOD9604s impact on body weight, adipose tissue mass, gene expression of 3-AR, and metabolic activity, as well as to evaluate whether the 3-AR is required for its effects [2]