Seek immediate medical attention (attend A&E or call 999) if blood in stool is accompanied by: Large volumes of bright red blood or continuous bleeding Dizziness, fainting, or signs of significant blood loss Severe abdominal pain or rigidity Vomiting blood or coffee-ground material Black, tarry stools with a foul odour (melaena), suggesting upper gastrointestinal bleeding Rapid heart rate, pallor, or confusion Contact your GP promptly (within 24-48 hours) if you notice: Small amounts of bright red blood on toilet paper or coating the stool Persistent change in bowel habits lasting more than three weeks Unexplained weight loss Persistent abdominal pain or bloating Blood mixed throughout the stool Recurrent episodes of rectal bleeding According to NICE guidance (NG12), patients aged 50 and over with unexplained rectal bleeding should be referred via a suspected cancer pathway (two-week wait) to exclude colorectal cancer

Cucumbers, watermelon, celery, oranges, strawberries, and lettuce all contain 90% or more water by weight
(Source: NEJM SELECT Trial, 2023) Semaglutide Also Reduces Fatty Liver Disease Risk A 2026 analysis of the SELECT trial found that semaglutide also reduces major heart events and lowers fatty liver disease risk in adults with both obesity and heart disease
Contact your healthcare provider or poison control immediately, do not take your next scheduled dose, and seek emergency care if you experience persistent vomiting, severe abdominal pain, or signs of dehydration
Practical strategies for managing concurrent treatment include: Maintain hydration Both medications can cause gastrointestinal upset, making adequate fluid intake essential
For short trips lasting less than the product-specific room temperature storage duration, patients can transport their medication at room temperature without refrigeration, provided temperatures remain below the maximum allowed (77F/25C for exenatide products