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Methylation of 7,8-DHF into O-methylated metabolites (7H8M-flavone and 8H7M-flavone) by COMT has been reported and these O-methylated metabolites appeared to have agonistic effects on TrkB receptors ( Ex vivo metabolism might have contributed to the quantitation of these metabolites

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In rare instances, supplements may be required, but dosage should be determined by a qualified healthcare provider

10 mg/kg for T-ALL) or ATO+MTX, as described above

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& Vukojevic, J