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Together, these findings necessitate further investigations to ascertain whether coordinated inhibition of NMDA receptors in GLP-1 receptor neurons modulates neuronal activity beyond canonical feeding regions, such as the mesolimbic dopaminergic reward pathway

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For instance, phenylacetylglutamine, a metabolite derived from microbial metabolism of dietary phenylalanine, has been associated with short sleep duration, mitochondrial dysfunction, and age-related comorbidities in humans (Krishnamoorthy et al., 2024

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