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Proc Natl Acad Sci USA 101 : 1803018035

As a selective substrate site-targeting inhibitor of nicotinamide N-methyltransferase (NNMT) the cytosolic enzyme responsible for the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor 5-Amino-1MQ is studied as a tool compound for investigating NNMT enzyme activity, NAD salvage pathway interactions, and methylation pathway dynamics in controlled in-vitro experimental systems

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Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation