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Another important gene that influences caffeines effects in the body is COMT (catechol-O-methyltransferase)

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The increase in total glutathione abundance, however, is coupled with an unbalanced activation of glutathione metabolic pathways

Also, GHK and GHK-Cu decreased TNF-alpha-dependent secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line [ 47 ]

Therefore, glycyrrhizin may be a new strategy for treating pigment deficiency-related diseases

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