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Progress should be assessed through body composition analysis, circumference measurements, and photos rather than scale weight alone, as muscle preservation can mask fat loss on the scale

Human Trials : Participants receiving 10 mg daily for 7 days showed increased fat metabolism with no adverse effects on glucose regulation

A 26-week diabetes study measured human activity at 1 mg, but its endpoint was blood sugar rather than long-term weight. A short outpatient cohort measured about 4.7% weight loss over four weeks at 2.5 mg. Below 1 mg, estimates rely on pharmacokinetics and mechanism

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