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For example, unrestricted ketogenic diets have been shown to increase mortality in mice, and supplementing the OHB precursor 1,3-butanediol has been shown to increase middle-aged mortality in normal mice but extend lifespan in aged mice (Tomita et al

Following chemotherapy, macrophages secrete interleukin-18 (IL-18), which in turn upregulates L-amino acid transporter protein 2 (LAT2) expression in tumour cells

48%, p = 0.02) than the placebo group

We followed the BCS approach as it provides a surrogate for in vivo bioequivalence studies

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The therapeutic potential of ferroptosis inhibition in MASLD merits further research, bearing in mind the potential need of patient stratification